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Minerva Anestesiologica 2000 May;66(5):307-313

Copyright © 2009 EDIZIONI MINERVA MEDICA

language: English

Nitric oxide: modulation of the pulmonary circulation

Bigatello L. M.

From the Department of Anesthesia and Critical Care Massachussets General Hospital Harvard Medical School, Boston, Massachusetts, USA


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Nitric oxide (NO) is synthetized throuhout the body by the enzyme NO synthase (NOS), cyclic GMP transduction pathway causes pulmonary vasodilatation anti-platelets aggregation and inhibition of leukocyte adhesion. Inducible NOS is expressed in leukocytes in response to a variety of inflammatory stimuli and can be inhibited by corticosteroids. Inhaled NO is a selective pulmonary vasodilator. In USA inhaled NO was approved by FDA for hypoxemic respiratory failure in infants and children. In adults it may be useful in various clinical therapy: pulmonary hypertension, lung transplantation, ARDS but new clinical investigations are necessary.

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