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Minerva Anestesiologica 1998 January-February;64(1-2):45-50

Copyright © 1998 EDIZIONI MINERVA MEDICA

language: Italian

Muscular enzymatic levels disorders and Malignant Hyperthermia susceptibility test. A preoperative study of a patient with CPK high level

Perugini M. 1, Montironi C. 1, Rocchi S. 2

1 Regione Marche, ASL 9 - Macerata, Servizio di Anestesia e Rianimazione; 2 Azienda Sanitaria Lancisi (Ancona), Servizio di Anestesia e Rianimazione


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The preoperative evaluation of the enzymatic level concerning the functioning of the neuromuscular system, is of particular importance. The diseases of these regions may lead to Malignant Hyperthermia (MH) in the course of general anaesthesia. The authors illustrate the case of a young asymptomatic patient with constantly high levels of CPK, who was later affected by Central Core Disease (CCD), a rare hereditary slow progressing myopathy strictly related to MH. The authors suggest tat preoperative CPK levels, though not predictive of a patient to develop MH, can allow identification of patients affected by clinically silent myopathies. This can also acquire legal importance in case of clinical MH manifestation.

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