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La Rivista Italiana della Medicina di Laboratorio 2021 Apr 21

DOI: 10.23736/S1825-859X.21.00097-9

Copyright © 2021 EDIZIONI MINERVA MEDICA

language: English

A rare form of circulating plasma cell, Mott cell-like, in COVID-19 patients

Luca P. DICEMBRE, Federica SPOLAORE, Luca G. MENGHINI, Patrizia PARISI, Adriano ANESI

Laboratory of Clinical Pathology, APSS of Trento, S. Chiara Hospital, Trento, Italy


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We present a rare hematological anomaly observed in peripheral blood smears from two patients who tested positive for COVID-19. We found reactive lymphocytes and large plasma cells with eccentric nuclei and cytoplasm filled with vacuolar inclusions, called Russel’s bodies. These particular plasma cells are most likely Mott cells. Though larger studies need to be carried out, Mott cell identification along with a systematic evaluation of morphologic changes in hematopoietic cells, could prove to be a straightforward and easy-to-perform supplementary diagnostic and prognostic tool in patients with SARS-Cov2 infection.


KEY WORDS: Mott cells; Covid-19; SARS-CoV-2; Hematology; Morphology

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