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La Rivista Italiana della Medicina di Laboratorio 2021 Giugno;17(2):108-14

DOI: 10.23736/S1825-859X.21.00098-0

Copyright © 2021 EDIZIONI MINERVA MEDICA

language: Italian

Biomarkers’ prognostic value in prediction of cardiovascular mortality in a cohort of institutionalized elderly

Sara VALVERDE 1, Roberto VALLE 2, Francesca GESSONI 1, Letizia VALLE 2, Gianluca GESSONI 3

1 UOC Medicina di Laboratorio, Ospedale della Navicella, Chioggia, Venezia, Italia; 2 UOC Cardiologia e Unità Coronarica, Ospedale della Navicella, Chioggia, Venezia, Italia; 3 UOC Medicina Trasfusionale, Ospedale dell’Angelo, Mestre, Venezia, Italia



BACKGROUND: Heart failure (HF) has been defined a modern pandemic. The complex array of physiologic, psychological, social and health care delivery issues makes it a challenging chronic disease to manage. Thus, our study sought to evaluate a multimarker approach to assess a prognosis of HF elderly patients.
METHODS: We considered 202 elderly in the nursing home in Chioggia (Venice, Italy). Each subject underwent clinical evaluation, echocardiography, determination of high sensitivity troponin I (hs-TnI), galectin-3 (GAL), cystatin C (CYS) and brain natriuretic peptides (BNP) using routine methods. These subjects were followed for 24 months after their inclusion in the study and during this period mortality due to cardiovascular diseases (SM) and mortality due to other diseases (OM) were recorded.
RESULTS: After a 24-months follow-up (FU), OM was 24% and SM was 18%. For BNP the relative risk (RR) was 2.5 for OM versus 7.5 for SM, for CYS 8.6 vs. 7.5, for GAL 2.7 vs. 5.6, for hs-TnI 2.2 vs. 3.8 respectively.
CONCLUSIONS: In the considered population BNP, GAL and hs-TnI, but not CYS, were associated with mortality due to cardiovascular diseases.


KEY WORDS: Biomarkers; Cardiovascular system; Mortality; Heart failure

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