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La Rivista Italiana della Medicina di Laboratorio 2021 Giugno;17(2):99-107

DOI: 10.23736/S1825-859X.21.00107-9

Copyright © 2021 EDIZIONI MINERVA MEDICA

language: Italian

Diagnostic value of highly sensitive cardiac troponins and mechanisms of their increase in serum and urine in arterial hypertension

Aleksey M. CHAULIN

Cattedra di Cardiologia e Chirurgia Cardiovascolare, Università Statale di Medicina di Samara, Samara, Russia



Over the past decade, immunochemical methods for laboratory testing of many biomarkers of cardiovascular diseases, including cardiac troponins (cTnT and cTnI), have been significantly improved, which has changed our understanding of their diagnostic consideration and offered new diagnostic opportunities for their implementation in clinical practice. New methods for the determination of cardiac-specific troponins, designated as highly sensitive (hs-cTnT and hs-cTnI), can identify even the most minor and reversible damage to the myocardium that occurs in many physiological states (for example, during physical exertions and stressful situations), and in the initial stages of many pathological conditions (for example, myocarditis, sepsis, renal failure, oncological pathologies, and others). However, elevated serum levels of hs-cTnT and hs-cTnI, corresponding to the degree of myocardial damage, have a high prognostic value, allowing to identify patients with a high risk of developing adverse cardiovascular events. Arterial hypertension (AH) is among the early but highly dangerous pathological conditions affecting the cardiovascular system. The article contains the systematized review of the results of clinical studies on the diagnostic and prognostic values of hs-cTnT and hs-cTnI in arterial hypertension in serum and other biological fluids that may be obtained by a non-invasive method. This paper also presents the potential mechanisms for increasing the concentration of hs-cTnT and hs-cTnI.


KEY WORDS: Hypertension; Prognosis; Troponin T; Troponin I; Blood pressure

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