ARTICOLO ORIGINALE   

La Rivista Italiana della Medicina di Laboratorio 2019 Settembre;15(3):196-201

DOI: 10.23736/S1825-859X.19.00014-8

Copyright © 2019 EDIZIONI MINERVA MEDICA

language: Italian

Evaluation of a multimarkers approach in the diagnosis of heart failure in geriatrics subjects

Sara VALVERDE ¹, Gianluca GESSONI ² ✉, Elisabetta GARELLI ³, Letizia VALLE ³, Francesca GESSONI ⁴, Massimo IACOVIELLO ⁵, Matteo ZATTA ³, Roberto VALLE ³

¹ Servizio di Medicina di Laboratorio, Ospedale Madonna della Navicella, Chioggia, Venezia, Italia; ² Servizio di Medicina Trasfusionale, Ospedale dell’Angelo, Mestre, Venezia, Italia; ³ Unità di Cardiologia e Coronarica, Ospedale Madonna della Navicella, Chioggia, Venezia, Italia; ⁴ Università di Padova, Scuola di Igiene e Sanità Pubblica, Padova, Italia; ⁵ Unità Operativa Complessa di Cardiologia Universitaria, Azienda Ospedaliera Universitaria Policlinico Consorziale di Bari, Bari, Italia

BACKGROUND: Heart failure (HF) has been defined a modern pandemic. The complex array of physiologic, psychological, social and health care delivery issues makes it a challenging chronic disease to manage. Our study thus sought to evaluate a multi markers approach in diagnosis of HF.
METHODS: 68 Italian males with age over 65 years were considered: 25 patients with HF; 18 repeat blood donors and 25 subjects recruited in a medical examination for not competitive sports activities. In these subjects determination of high sensitivity troponin I (HS-TNI), galectin (GAL), cystatin (CYS) and brain natriuretic peptide were performed by using routine methods.
RESULTS: Among HF patients with heart failure mean concentration HS-TNI, GAL, CYS and BNP was significantly higher than values observed in blood donors and not competitive sports activities. In this study, for differentiation of HF patients and blood donor or not competitive sports activities subjects, better parameters were GAL (CCI 0.97) and BNP (CCI 0.93).
CONCLUSIONS: Our study showed the usefulness of a strategy involving multiple biomarkers determination in laboratory diagnosis of heart failure in elderly males.

KEY WORDS: Biomarkers; Natriuretic peptide, brain; Cystatins; Galectins; Heart failure; Troponin