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La Rivista Italiana della Medicina di Laboratorio 2019 Giugno;15(2):91-9

DOI: 10.23736/S1825-859X.19.00031-8

Copyright © 2019 EDIZIONI MINERVA MEDICA

language: Italian

Chronic diseases and laboratory medicine

Piero CAPPELLETTI

SIPMeL, Castelfranco Veneto, Treviso, Italia



The Laboratory Medicine has an essential role in the chronic diseases, through specific “biomarkers” used for screening, diagnosis and differential diagnosis, prognosis and risk stratification, follow up and monitoring of therapy, and as surrogate endpoints. The Clinical Guidelines of the Chronic Diseases establish the appropriate use of biomarkers. Nevertheless, some issues remain: in the Clinical Guidelines generally lack complete information of characteristics of biomarkers; the appropriateness is very complex in the preclinical phase and in the terminal phase of the chronic diseases; the “personalization” of patients’ treatment is very difficult for clinical and organizational issues, and for the gap between innovation, evidence and codified clinical recommendation in the Guidelines.


KEY WORDS: Laboratory Medicine; Chronic disease; Biomarkers

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