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La Rivista Italiana della Medicina di Laboratorio 2019 Marzo;15(1):30-9

DOI: 10.23736/S1825-859X.19.00002-1

Copyright © 2018 EDIZIONI MINERVA MEDICA

language: Italian

Acute kidney injury biomarkers. Part 1: clinical and managing aspects

Maria GOLATO

ASL02 Lanciano-Vasto-Chieti, Lanciano, Chieti, Italia



The acute kidney injury (AKI) is a complex syndrome with a multifactorial etiology and with a high mortality and morbidity rate, if not diagnosed at the beginning. Hence the need to have guidelines that can help the clinician in choosing the optimal management of the patient and biomarkers that allow an early diagnosis in order to avoid the occurrence of short and long-term complications. The development of new biomarkers able to overcome the limits of current diagnostic derives primarily from the understanding of the pathogenic mechanism that underlies AKI, that is the cellular damage from which a series of cascade mechanisms are triggered, which include the inflammatory response, cell cycle arrest, apoptosis and cell regeneration. Currently we have a large number of biomarkers; nevertheless, the desired target of identifying a “renal troponin” has not yet been reached and the main reasons are the complexity of the AKI that makes it different from the cardiac ischemic pathology and the heterogeneity of the populations under study overall. In part 1 of this review of the literature, we have tried to summarize the defining issues, the diagnostic criteria in the adult and pediatric population and the managing aspects of AKI that represent the framework of the use of AKI biomarkers.


KEY WORDS: Acute kidney injury; Kidney diseases; Biomarkers

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