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Medicina dello Sport 2021 December;74(4):694-705

DOI: 10.23736/S0025-7826.21.03872-2

Copyright © 2021 EDIZIONI MINERVA MEDICA

language: English, Italian

Effects of eight weeks of aerobic exercise and vitamin D supplementation on leptin, adiponectin, and glycemic control indices in men with type 2 diabetes

Hamid AHMADI , Mohsen GHANBARZADEH, Roohollah RANJBAR, Masood NIKBAKHT

Department of Exercise Physiology, Faculty of Sport Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran


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BACKGROUND: Obesity, a sedentary lifestyle, and vitamin D deficiency are linked closely to diabetes. This study aims to evaluate effects of aerobic exercise and vitamin D supplementation on adipokines and glycemic control indices in type 2 diabetic patients.
METHODS: Forty-two men with type 2 diabetes (49.5±0.81 years, BMI 29.6±1.3 kg/m2) were assigned randomly into four groups of aerobic exercise + vitamin D supplementation (N.=11), aerobic exercise (N.=10), vitamin D supplementation (N.=10) and control (N.=11). The aerobic exercise program was implemented for eight weeks, with an intensity of 50-75% of heart rate reserve. The supplementation groups received vitamin D supplements at a dose of 4000 IU daily. Levels of vitamin D, leptin, adiponectin, HbA1c, HOMA-1R and QUICKI were measured in the pre-test and after eight weeks of intervention.
RESULTS: The levels of leptin and adiponectin in the aerobic exercise + vitamin D supplementation group had a significant decrease and increase respectively compared to the vitamin D group (P<0.05), but compared to the aerobic exercise group did not differ significantly (P>0.05). Furthermore, the percentage of HbA1c in the aerobic exercise + vitamin D supplementation group compared to the aerobic exercise group and the vitamin D supplementation group showed significant differences (P<0.05).
CONCLUSIONS: Aerobic exercise seems to be a more effective strategy than vitamin D supplementation to changes leptin and adiponectin levels in men with type 2 diabetes. However, the improvement of HbA1c in diabetic patients is not associated with changes in leptin and adiponectin.


KEY WORDS: Type 2 diabetes mellitus; Anaerobic threshold; Exercise; Vitamin D; Adipokines; Glycated hemoglobin A

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