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Medicina dello Sport 2015 June;68(2):217-29


language: English, Italian

Contrasting effect of submaximal exercise on circulating vascular endothelial growth factor under different oxygen status

Nourshahi M. 1, Hedayati M. 2, Karimi F. 1, Ranjbar K. 3

1 Department of Exercise Physiology, Faculty of physical Education and sport sciences, Shahid Beheshti University, Tehran, Iran; 2 Obesity Research Center, Research Institute of Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 3 Department of Exercise Physiology, Faculty of physical Education and sport sciences, Bu-Ali Sina University, Hamedan, Iran


Vascular endothelial growth factor (VEGF) is an important mediator causes angiogenesis in vitro which is up regulating via hypoxia. But data about VEGF regulating in hypoxic condition are conflicting in vivo. Discrepancy in results is probably based on differences in intensity of hypoxia during the studies. Therefore, the present applied study investigated the effect of a single bout of exercise on the serum VEGF under different oxygen status. For this purpose, ten healthy men participated in this study. VO2max was determined on cycle ergometer under normoxia 21% O2, normobaric hypoxia 16% O2, normobaric hypoxia 15% O2 and normobaric hypoxia 14% O2 conditions. Each step was separated with 72 h washout. Moreover, all subjects performed and completed a 1-h cycle ergometer exercise bout at 50% of VO2max of each oxygen status. Three blood samples (pre exercise, immediately post and 2 hours post exercise) were collected from an antecubital vein from each subject at each exercise session. The hypoxic conditions were induced by using a normobaric hypoxic chamber. The results of the study showed that acute exercise increased serum VEGF under hypoxia 14% O2, unchanged in hypoxia 15%O2 and 16%O2, but serum VEGF decreased under normoxia 21%O2 in response to submaximal exercise (P<0.001). Moreover, SaO2 decreased significantly in response to exercise under different oxygen status (P=0.02). This study demonstrates for the first time that different oxygen status have a different effect on circulating serum VEGF in response to submaximal exercise in vivo. These results may provide a way of understanding the mechanisms of VEGF regulating in humans and may cause interest among athletes to improve their sea-level performance.

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