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Medicina dello Sport 2012 June;65(2);187-97


language: English, Italian

Influence of vitamin C moderate dose supplementation on exercise-induced lipid peroxidation, muscle damage and inflammation

Bohlooli S. 1, Rahmani-Nia F. 2, Babaei P. 3, Nakhostin-Roohi B. 4

1 Department of Pharmacology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran; 2 Department of Exercise Physiology, Guilan University, Rasht, Iran; 3 Cellular and Molecular Research Center, Guilan University of Medical Sciences, Rasht, Iran; 4 Department of Exercise Physiology, Ardabil Branch, Islamic Azad University, Ardabil, Iran


Aim. The purpose of this study was to evaluate the effect of moderate dose vitamin C supplementation on exercise-induced lipid peroxidation, muscle damage and inflammation.
Methods. Sixteen healthy untrained male individuals participated in a 30-min exercise at 75% VO2max. Subjects were randomly assigned to one of two groups: 1) placebo (P) and 2) vitamin C (VC: 500 mg vitamin C). Blood samples were obtained prior to supplementation (baseline), 2 h after supplementation (immediately pre-exercise), immediately, 2 and 24 h after exercise. Plasma levels of vitamin C, total antioxidant capacity (TAC), creatine kinase (CK), malondealdehyde (MDA), total leukocytes, neutrophils, lymphocytes, interleukin-6 (IL-6), and CRP were measured.
Results. With supplementation, plasma vitamin C concentration increased significantly only in the VC group (P<0.05). TAC decreased significantly just in P group, 2 and 24 h after exercise (P<0.05). Although MDA levels were similar between groups at the baseline, only in the P group it increased significantly after exercise (P<0.05). CK increased immediately and 2 h after exercise in both groups and 24 h after exercise just in placebo group compared with pre-exercise (P<0.05). Markers of inflammation (total leukocytes, neutrophils, CRP and IL-6) increased significantly in response to the exercise in both groups (P<0.05).
Conclusion. In conclusion, it seems that vitamin C acute moderate dose supplementation affects exercise-induced lipid peroxidation and muscle damage, but not inflammatory markers.

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