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Medicina dello Sport 2001 December;54(4):319-23

Copyright © 2001 EDIZIONI MINERVA MEDICA

language: English

Effect of an intensive exercise of short duration on the expression of TNF-α and receptor TNF-R1 (sTNF) in the blood serum

Monkiewicz M. 1, Kuliczkowski K. 2, Zagrobelny Z. 1

1 Institute of Physiotherapy, Academy of Physical Education in Wroclaw; 2 Department of Haematology, Wroclaw Medical University


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A group of subjects performed an intensive progressive “vita maxima” test of short duration. The samples of venous blood were taken before and immediately post-exercise. The levels of TNF-α and its receptor TNF-R1 in the blood serum were measured using the ELISA method (R&D Systems, UK). The mean work output of 215.6 kJ resulted in statistically significant increase in levels of TNF-α (p=0.000001) and TNF-R1 (p=0.0003) in the blood serum. It seems that serum TNF-R1 after the proteolytic shedding from the cell membrane is an effective inhibitor of apoptosis induced by the TNF-α production stimulated by an intensive physical exercise.

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