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Medicina dello Sport 1999 September;52(3):165-75


language: Italian

The end of antioxiding treatment for polmonary illness. Our experience

Cristofalo M. G., Savojardo M., Pecorella G., Galiano S., Lo Coco L., Parisi A., Francavilla V., Marchese L., Palmieri F., Francavilla G.

Cattedra di Medicina dello Sport, Università degli Studi, Palermo


We made lots of researches about free radicals.
In several pathologies, statistically responsible for deadly and invalidating diseases, direct connections with the production and the presence of oxiding substances came over.
The respiratory free is surely the first to be damaged by free radicals. The performance of athletes was also monitored in order to find logical explanations of sudden collapse of training.
The lung is one of organs which is produced by pollutions and by lowered defences of immunity.
Our work about BIEF, leaving from a sure date, we refer to oxidising activity produced not only by N-Acetilcisteina with its double actions but also by the important oxidation-reduction last carried out by vitamin C, wants to get a pharmacological prevention about inducted broncospasm.
Sixty-two athletes were randomized and divided in 4 groups: the under control group D formed by 16 healthy athletes, the group A, B, C one broncospasme, caused by hard training.
Cough, thoracic compulsion, dyspnea were symptomatologies; some athletes were afflicted by a decreased athletic efficiency and abdominal pain.
The four groups, which went in for to the same sport, had the same average age, the same sex; they were examined in the same climatic and environmental conditions. They were put to the afford treadmill test; their maximum cardiac beats reached 80-85%. Of course inspirometric test, before of the afford, asserts that their statistical and dynamic pulmonary volume was good.
After their physical afford they were put to the inspirometer tests at 1’, 5’, 10’, 20’, 25’, 30’, in order to examine the main branch construction parameters: FEV1, PEF, MEF50, MEF75.
The FEV1 and PEF tests were estimated good as there was a lowering of 15-20% if we consider the basical. The athletes, who belonged to the third group and which were affected by one event of anamnesis BIEF at least, repeated the crise during and after their physical, afford by the thirtieth minute. The group D didn’t have symptoms or alterations on inspirometer dates. The group A, suffering from BIEF, were treated by NAC 200 mg/die + vitamin C 1 g/die therapy for 4 months. The group B, afflicted by BIEF were treated by placebo effect. The group C, afflicted by BIEF were not treated. The group D, composed by healthy athletes were taken as control group.
All the athletes, who belonged to the four groups, followed a homogeneous training for 4 minutes.
In the end the results confirmed what we had supposed about the positive treatment of N-Acetilcisteina and vitamin C in patients suffering from BIEF.
All in all the athletes who belonged to group A, had a significative syntomatological modification as well as a total remission of the illness.

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