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European Journal of Oral and Maxillofacial Surgery 2019 April;3(1):17-20

DOI: 10.23736/S2532-3466.18.00149-2

Copyright © 2018 EDIZIONI MINERVA MEDICA

language: English

IgG4-related sialadenitis of the right submandibular gland

Antonio DELL'AQUILA 1 , Annachiara SALVATO 1, Gabriele VITIELLO 1, Daniele SORANO 1, Luigi VECCHIONE 2, Graziella DI GREZIA 3

1 Unit of Oral and Maxillofacial Surgery, Del Mare Hospital, ASL Napoli 1 Centro, Naples, Italy; 2 Unit of Odontostomatology, Pellegrini Hospital, ASL Napoli 1 Centro, Naples, Italy; 3 Department of Radiology, G. Criscuoli Hospital, Sant’Angelo dei Lombardi, Avellino, Italy



IgG4-related sialadenitis (IgG4-RS) is a benign inflammatory autoimmune disease of the major salivary glands. Immunoglobulin G4-related diseases represent recently introduced multi-organ diseases that also involve the salivary glands. (IgG4-RS)/Küttner tumor is a fibroinflammatory process that characteristically involves the submandibular gland of patients with IgG4-related disease. Histologic examination is often important to make the diagnosis because of its nonspecific clinical and radiologic findings. Microscopically, (IgG4-RS) should be distinguished from other entities such as extranodal marginal zone lymphoma, Sjogren’s Syndrome, and lymphoepithelial sialadenitis. Clinicians and pathologists should consider the diagnosis of IgG4-RS/Küttner tumor in patients with elevated serum IgG4 level. Timely and accurate diagnosis is important for appropriate management.


KEY WORDS: Sialadenitis - Immunoglobulin G4-related disease - Mandibular neoplasms

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