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European Journal of Oral and Maxillofacial Surgery 2017 December;1(3):93-7

DOI: 10.23736/S2532-3466.17.00124-2

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

Localized amyloidosis on the midline dorsum of the tongue: differential diagnosis and treatment

Giuseppe COLELLA, Atirge CECERE , Gianpaolo TARTARO

Department of Maxillofacial Surgery, “Luigi Vanvitelli” University, Naples, Italy


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A 43-year-old Caucasian presented a lesion involving the dorsal tongue, on the midline. The differential diagnosis of the lesions of the tongue dorsum can be difficult. It includes various types of benign and malignant processes. Histopathological examination of hematoxylin-eosin revealed extracellular deposition of amyloid. Localized amyloidosis of the tongue involves generally the margins, as reported in literature. In the present case the dorsum of the tongue was involved: this very unusual localization makes more difficult the differential diagnosis. When diagnosis of tongue amyloidosis was confirmed histologically, a systemic involvement must be excluded. Anyway, only therapy of tongue amyloidosis is surgical excision, eliminating the discomfort due to the mass. The prognosis is poor in systemic disease, but in the localized tongue amyloidosis currently it is only recommended a periodic follow-up to rule out the occurrence of systemic disease. Lesion of the tongue are very frequent and miscellaneous, and sometimes differential diagnosis is difficult. We believe useful not only to show the present case (a very unusual localization and clinical presentation of primary amyloidosis) but also to discuss the benign and malignant pathologies that must be considered in the differential diagnosis of the lesion of tongue dorsum; at the best of our knowledge, no work that we read analyzes in detail these issues.


KEY WORDS: Tongue - Amyloidosis - Diagnosis - Therapeutics

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Publication History

Issue published online: November 9, 2017
Manuscript accepted: October 4, 2017
Manuscript received: September 18, 2017

Cite this article as

Colella G, Cecere A, Tartaro G. Localized amyloidosis on the midline dorsum of the tongue: differential diagnosis and treatment. Eur J Oral Maxillofac Surg 2017;1:93-7. DOI: 10.23736/S2532-3466.17.00124-2

Corresponding author e-mail

atirge.cecere@gmail.com