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EUROPEAN JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY

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European Journal of Oral and Maxillofacial Surgery 2017 April;1(1):6-17

DOI: 10.23736/S2532-3466.17.00102-3

Copyright © 2016 EDIZIONI MINERVA MEDICA

language: English

Functional effect of pulsed electromagnetic fields treatment combined with silicone grafting on transected sciatic nerve regeneration in rat

Rahim MOHAMMADI 1, Moein MEHRTASH 1, Hamed MIRZAEI-RAD 1, Moeid MEHRTASH 2, Saeed NAFISI 3

1 Department of Surgery and Diagnostic Imaging, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran; 2 Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia Branch, Islamic Azad University, Urmia, Iran; 3 Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran


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BACKGROUND: The effect of whole body exposure to pulsed electromagnetic fields (PEMF) on nerve regeneration in a rat sciatic nerve transection model was assessed.
METHODS: Sixty male white Wistar rats were randomly divided into four experimental groups (N.=15): in transected group (TC) left sciatic nerve was transected and stumps were fixed in adjacent muscle. In silicone group (SIL/SHAM) the defect was bridged using a silicone conduit filled with phosphate-buffered saline. In treatment group (SIL/PEMF) the whole body was exposed to PEMF (0.3 mT, 2Hz) for 4 h/day within 1-5 days. In normal control group (NC) sciatic nerve was only exposed and manipulated. Each group was subdivided into three subgroups of five animals each and nerve fibers were studied 4, 8 and 12 weeks after surgery.
RESULTS: Behavioral, functional, electrophysiological, biomechanical, gastrocnemius muscle mass findings and morphometric indices confirmed faster recovery of regenerated axons in SIL/PEMF than in SIL group (P<0.05). Immunohistochemical reactions to S100 in SIL/PEMF were more positive than that in SIL/SHAM group. Whole body exposure to PEMF improved functional recovery and morphometric indices of sciatic nerve.
CONCLUSIONS: PEMF could be considered as an effective, safe and tolerable treatment for facial nerve repair in clinical practice.


KEY WORDS: Peripheral nerves - Sciatic nerve - Rats - Nerve regeneration

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Publication History

Issue published online: March 23, 2017
Manuscript accepted: December 2, 2016
Manuscript received: November 21, 2016

Cite this article as

Mohammadi R, Mehrtash M, Mirzaei-Rad H, Mehrtash M, Nafisi S. Functional effect of pulsed electromagnetic fields treatment combined with silicone grafting on transected sciatic nerve regeneration in rat. Eur J Oral Maxillofac Surg 2017;1:6-17

Corresponding author e-mail

r.mohammadi@urmia.ac.ir