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International Angiology 2020 Oct 21

DOI: 10.23736/S0392-9590.20.04479-X

Copyright © 2020 EDIZIONI MINERVA MEDICA

language: English

Blood adipocytokine concentration in patients with peripheral artery disease

Marta SPYCHALSKA-ZWOLIŃSKA 1, Marzena ANASZEWICZ 1, Joanna WIŚNIEWSKA 1, Artur MIECZKOWSKI 1, Gabriel KOWALCZYK 1, Wioletta BANAŚ 1, Beata CZERNIAK 1, Karol SUPPAN 1, Kinga LIS 2, Magdalena ŻBIKOWSKA-GOTZ 2, Zbigniew BARTUZI 2, Jacek BUDZYŃSKI 1

1 Department of Vascular and Internal Diseases, Nicolaus Copernicus University in Toruń, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Bydgoszcz, Poland; 2 Department of Allergology, Clinical Immunology and Internal Diseases, Nicolaus Copernicus University in Toruń, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Bydgoszcz, Poland


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BACKGROUND: Inflammatory responses mediated by adipocytokines may affect both atherosclerosis development and progression, as well as the risk of in-stent restenosis. The aim of this study was to determine the relationships between blood leptin, adiponectin and tumor necrosis factor-alpha (TNF-alpha) concentrations and the 1-year outcome of superficial femoral artery (SFA) stenting.
METHODS: Blood concentrations of leptin, adiponectin and TNF-alpha were determined in 70 patients undergoing SFA stenting due to intermittent claudication and in 40 patients undergoing carotid artery stenting (CAS). All subjects were followed up for at least 1 year in relation to the occurrence of clinically driven target lesion revascularization (TLR) or a major adverse cardiovascular event (MACE).
RESULTS: Patients undergoing SFA stenting and CAS had similar blood adipocytokine concentrations. Patients with diabetes mellitus presented a higher leptin concentration, lower adiponectin-to-leptin ratio, and lower blood adiponectin concentration indexed to fat mass (FM) and to visceral adiposity score (VAS). In Kaplan-Meier analysis, blood concentration of TNF-alpha indexed to FM and to VAS was higher in patients who underwent TLR and MACE. However, in multifactorial analysis, the severity of atherosclerosis lesions in the femoropopliteal vascular region, estimated in relation to TASC-II classification, was the only predictor of TLR.
CONCLUSIONS: Circulating adipocytokines did not distinguish patients with different clinical manifestations of atherosclerosis. Higher ratios of TNF-alpha-to-FM and to VAS before SFA stenting were related to TLR and MACE occurrence. Dysregulation in adipocytokine secretion may be a potential mediator of a pro-atherogenic action of diabetes mellitus in patients with peripheral artery disease.


KEY WORDS: Adiponectin; In-stent restenosis; Leptin; Peripheral artery disease; TNF-alpha

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