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International Angiology 2015 June;34(3):195-201

Copyright © 2015 EDIZIONI MINERVA MEDICA

language: English

Matrix metalloproteinases and peripheral arterial disease

Giagtzidis I. 1, Karkos C. 1, Pitoulias G. 2, Papazoglou K. 1

1 Fifth Surgical Department, Hippokrateio General Hospital, Thessaloniki, Greece; 2 Surgical Department, Georgios Gennimatas General Hospital, Thessaloniki, Greece


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It has been postulated that atherosclerosis should be considered as a chronic inflammatory process and peripheral arterial disease (PAD) is a manifestation of such an atherosclerotic vascular disease. Matrix metalloproteinases (MMPs) are significant circulating biomarkers which play a pivotal role in the initiation, progression and clinical manifestations of PAD. This review summarizes the current body of evidence with regard to the association between MMPs and PAD.

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