ORIGINAL ARTICLES   

International Angiology 2014 October;33(5):455-60

Copyright © 2014 EDIZIONI MINERVA MEDICA

language: English

A decreased serum omentin-1 level may be an independent risk factor for peripheral arterial disease

Onur I. ¹, Oz F. ¹, Yildiz S. ², Kuplay H. ³, Yucel C. ³, Sigirci S. ², Elitok A. ¹, Pilten S. ⁴, Kasali K. ⁵, Yasar Cizgici A. ¹, Erentug V. ³, Dinckal H. M. ² ✉

¹ Department of Cardiology, Istanbul School of Medicine, Istanbul University, Istanbul, Turkey; ² Cardiology Clinic, Bagcilar Education and Research Hospital, Istanbul, Turkey; ³ Cardiovascular Surgery Clinic, Bagcilar Education and Research Hospital, Istanbul, Turkey; ⁴ Department of Biochemistry, Bagcilar Education and Research Hospital, Istanbul, Turkey; ⁵ Department of Biostatistics, Istanbul School of medicine, Istanbul University, Istanbul, Turkey

AIM: Recent evidence suggests that omentin-1, a visceral adipose-derived cytokine, may play a role in atherosclerosis The aim of this study was to evaluate whether serum omentin-1 levels are associated with peripheral artery disease (PAD) and its severity.
METHODS: The present study was cross-sectional and observational. We enrolled 123 patients with PAD and 50 age-matched subjects without PAD. The cardiovascular risk factors, ankle-brachial index (ABI), and serum omentin-1 levels were assessed in all participants.
RESULTS: Patients with PAD had significantly lower omentin-1 levels than those without PAD (206. ±48.4 vs. 345. ±80 ng/mL, respectively; 0.001). A correlation analysis revealed positive correlations between the omentin-1 level and the ABI ( 0.52, P=0.008). After adjusting for cardiovascular risk factors, a decreased omentin-1 level was found to be an independent predictor of both PAD and its severity as measured by ABI in multivariate logistic regression analysis.
CONCLUSION: The current study suggests a strong association between decreased serum omentin-1 levels and PAD and its severity. Thus, omentin-1 may be a novel biomarker for PAD.