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International Angiology 2010 December;29(6):496-506

Copyright © 2010 EDIZIONI MINERVA MEDICA

language: English

IL-6, TNF-alpha, IL-1-beta arterial wall expression is independent of serum concentration in patients sustaining primary or secondary open vascular reconstructions

Stanisić M. 1, Majewski W. 1, Zurawski J. 2, Lesniewska K. 3, Majewski P. 2

1 Department of General and Vascular Surgery, Poznan University of Medical Sciences, Poznan, Poland; 2 Department of Clinical Pathomorphology, Poznaƒ University of Medical Sciences, Poznan, Poland; 3 Department of Biology and Environmental Studies, Poznan University of Medical Sciences, Poznan, Poland


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AIM: The aim of this study was to assess morphological and immunohistochemical differences in arterial wall inflammation during primary and secondary vascular reconstructions.
METHODS: Forty patients with lower extremities ischemia underwent vascular reconstruction: Group I included patients undergoing primary vascular reconstruction with 25 minor arterial reconstructive procedures; Group II included patients undergoing secondary reconstruction due to limb ischemia after at least 12 months since first operation (15). Immunohystochemical expression of IL-1-BETA,IL-6,and TNF-alpha in arterial wall was correlated with serum concentration.
RESULTS: No differences were observed in IL-1-beta, IL-6, TNF-alpha expression among groups (P=0.06, P=0.13, P=0.9). Cytokines expression was not accompanied by the growth of its serum concentrations (P=0.8, P=0.9). IL-6 serum concentration depended on the degree of limb ischemia and was very high in case of critical limb ischemia (P=0.006). Arterial morphology was comparable among the groups.
CONCLUSION: IL-6, IL-1-BETA, TNF-alpha expression in the arterial wall is comparable in primary and secondary lesions. Serum concentrations of IL-6, IL-1-BETA, TNF-alpha are independent of its arterial wall expression.

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