Home > Journals > International Angiology > Past Issues > International Angiology 2006 December;25(4) > International Angiology 2006 December;25(4):335-42



Publishing options
To subscribe
Submit an article
Recommend to your librarian




Original articles   

International Angiology 2006 December;25(4):335-42


language: English

Prevention of major venous thromboembolism following total hip or knee replacement: a randomized comparison of low-molecular-weight heparin with unfractionated heparin (ECHOS Trial)

Haas S. 1, Breyer H. G. 2, Bacher H. P. 3, Fareed J. 4, Misselwitz F. 5, Victor N. 6, Weber J. 7, on behalf of Echos Trial Group

1 Institute for Experimental Oncology and Therapy Research, Technical University of Munich, Munich, Germany 2 Sankt-Gertrauden-Krankenhaus, Berlin, Germany 3 Abbott Laboratories, Global Pharmaceutical Research and Development, Abbott Park, IL, USA 4 Department of Pathology and Pharmacology, Loyola University Medical Center, Maywood, IL, USA 5 Abbott GmbH & Co KG Deutschland, Heidelberg, Germany (Present address: Heidelberg, Germany) 6 Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany 7 Dr. Guth Clinic, Hamburg, Germany


Aim. Venous thromboembolism remains a frequent complication after total hip or knee replacement surgery despite routine prophylaxis. However, the ability of pharmacologic thromboprophylaxis to prevent major venous thromboembolism, defined as proximal deep vein thrombosis, and/or pulmonary embolism, and/or death, has not been previously validated.
Methods. In a double-blind randomized study, 2018 patients, undergoing either total hip or knee replacement surgery, were allocated to receive subcutaneous preoperative reviparin (4200 anti Xa IU) once daily or 7500 IU unfractionated heparin twice daily, for a minimum of 11 days. The primary efficacy outcome was major venous thromboembolism, defined as the composite of venographically confirmed proximal deep vein thrombosis, and/or symptomatic pulmonary embolism and death, recorded up to day 14.
Results. The primary efficacy outcome was assessed in 1628 patients and demonstrated a significant reduction in the reviparin group (3.4% [28 of 813 patients] compared with unfractionated heparin (5.5% [45 of 815]) (odds ratio, 0.61; 95% confidence interval, 0.38 to 0.99, P=0.04) by day 11 to 14. A significant reduction in venous thromboembolism was maintained up to 6-8 weeks (3.4% [28 of 813 reviparin patients] versus 5.6% [46 of 815 unfractionated heparin patients]) (odds ratio, 0.6; 95% confidence interval, 0.37 to 0.97, P=0.03). Major bleeding events occurred in 9 reviparin-treated patients (0.9%) and in 12 unfractionated heparin-treated patients (1.2%).
Conclusions. Prophylaxis with reviparin significantly reduces the risk of major venous thromboembolism compared with unfractionated heparin in patients undergoing elective hip or knee replacement without increasing the risk of bleeding.

top of page