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International Angiology 2003 December;22(4):431-7

Copyright © 2003 EDIZIONI MINERVA MEDICA

language: English

Effect of diclofenac sodium on the healing process of end-to-end anastomosis in carotid arteries of rabbits. Histopathological and biomechanical studies

Freire Cerqueira N. 1, Hussni C. A. 1, Bonetti Yoshida W. 2, Swain Müller S. 2, Sequeira J. L. 3, Rodrigues A. C. 4, Mattar L. 2, Crocci A. J. 5

1 Veterinary Surgery and Anesthesiology, School of Veterinary Medicine and Animal Science, São Paulo State University, São Paulo, Brazil 2 Department of Surgery and Orthopedics, School of Medicine, São Paulo State University, São Paulo, Brazil 3 Department of Clinical Veterinary, School of Veterinary Medicine and Animal Science, São Paulo State University, São Paulo, Brazil 4 Department of Anatomy, Institute of Biosciences, São Paulo State University, São Paulo, Brazil 5 Department of Bioestatistics, Institute of Biosciences, São Paulo State University, São Paulo, Brazil


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Aim. Diclof­e­nac sodi­um is a non-ster­oid­al anti-inflam­ma­to­ry drug com­mon­ly used to atten­u­ate pain­ful inflam­ma­to­ry reac­tions in sur­gery. How­ev­er, it may delay heal­ing in the skin and gas­troin­tes­ti­nal tract. The aim of this study was to eval­u­ate the influ­ence of Diclof­e­nac in vas­cu­lar heal­ing.
Meth­ods. Nine­ty rab­bits had their carot­id arter­ies sec­tioned and recon­struct­ed by end-to-end anas­tom­o­sis with inter­rupt­ed ­sutures. The ani­mals were ran­dom­ly allo­cat­ed into 3 ­groups of 30 each and treat­ed by intra­mus­cu­lar route with ­saline (con­trol), 5 mg/kg/day of diclof­e­nac sodi­um (DS-5), and 10 mg/kg/day of diclof­e­nac sodi­um (DS-10). Treat­ment began on the day of sur­gery and last­ed 4 days. Angio­gra­phy, bio­me­chan­i­cal prop­er­ties (fail­ure load, fail­ure elon­ga­tion, yield point, yield point elon­ga­tion, and stiff­ness were ­obtained from the load/elon­ga­tion curve), mac­ro­scop­ic and his­to­log­i­cal exam­ina­tions (hem­a­tox­y­lin-eosin, Mas­son, Cal­le­ja, Picros­sir­i­us-red), and scan­ning elec­tron micros­co­py were stud­ied in both arter­ies on the 3rd and 15th post­op­er­a­tive days.
­Results. No sig­nif­i­cant dif­fer­enc­es in bio­me­chan­i­cal prop­er­ties were ­observed ­either in the 3 ­groups or the experi­men­tal times. The carot­id ­artery heal­ing pro­cess was sim­i­lar in the 3 ­groups.
Con­clu­sion. Diclof­e­nac sodi­um did not cause alter­a­tions nor ­delayed carot­id ­artery heal­ing.

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