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International Angiology 2001 September;20(3):214-7

Copyright © 2002 EDIZIONI MINERVA MEDICA

language: English

Gelatine-resorcine-formol glue as a sealant of ePTFE patch suture lines

Rittoo D., Sintler M., Burnley S., Millns P., Smith S., Vohra R.

From the Department of Vascular Surgery, * Department of Anaesthetics, Selly Oak Hospital University Hospital Birmingham NHS Trust, Birmingham, UK


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Back­ground. ePTFE patch recon­struc­tion has super­i­or flow char­ac­ter­is­tics in pre­vent­ing early throm­bus for­ma­tion dur­ing carot­id endar­te­rec­to­my. How­ev­er pro­longed bleed­ing at the ­suture line of the patch recon­struc­tion is a prob­lem. The aim of this study was to inves­ti­gate wheth­er the appli­ca­tion of gel­a­tine-resor­ci­ne-for­mol (GRF) glue at the ­suture line can ­improve local hae­mos­ta­sis.
Meth­ods. A pros­pec­tive ran­dom­ised trial of 40 con­sec­u­tive ­patients under­go­ing carot­id endar­te­rec­to­my was under­tak­en. ­Patients were ran­dom­ised to ­receive GRF glue as a top­i­cal haem­os­tat­ic agent or to act as con­trols. Sta­tis­ti­cal anal­y­sis was per­formed using the Mann-Whit­ney test.
­Results. ­Although the patch size was sig­nif­i­cant­ly small­er in the con­trol group (3.0 cm2 vs 4.3 cm2, p<0.001), local hae­mos­ta­sis was ­achieved in half the time when the glue was used (11 min­ vs 22, p<0.004). In the fol­low-up peri­od rang­ing from 12 to 24 ­months, there have been no ­adverse ­effects relat­ed to the glue. Two ­patients died dur­ing the fol­low-up peri­od. These ­deaths were nei­ther relat­ed to the patch nor to the glue.
Con­clu­sions. This study has shown that GRF glue is an effec­tive seal­ant of ePTFE patch ­suture line. GRF glue does not com­pro­mise the ­patch’s char­ac­ter­is­tics.

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