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International Angiology 2000 September;19(3):206-211


language: English

Risk factors in young patients with peripheral atherosclerosis

Kröger K., Buss C., Goyen M., Renzing-Köhler K., Rudofsky G.

From the Department of Angiology, * Institute for Medical Informatics, Biometrics and Epidemiology University Hospital Essen, Essen, Germany


Back­ground. Risk fac­tors and espe­cial­ly the com­bi­na­tion of mul­ti­ple risk fac­tors are asso­ciat­ed with the devel­op­ment of ath­ero­scler­o­sis. There­fore, ­patients with an early man­i­fes­ta­tion of ath­e­ros­cle­rot­ic dis­ease are like­ly to show an extraor­di­nary risk pro­file. We ana­lysed the fre­quen­cies and sever­ity of risk fac­tors in young ­patients with man­i­fest periph­er­al arte­ri­al occlu­sive dis­ease as com­pared to old ­patients.
Metho­ds. We ana­lysed the risk pro­files in 303 ­patients who were sent for inter­ven­tion­al treat­ment of a symp­to­mat­ic periph­er­al arte­ri­al occlu­sive dis­ease. The risk pro­files were ­described for dif­fer­ent age ­groups (54 ­patients under 50 years of age, 194 ­patients from 51 to 74 years, 55 ­patients over 75 years). Mul­ti­ple lin­e­ar regres­sion anal­y­sis and anal­y­sis of var­i­ance were per­formed to look for age-depen­dent ­effects.
­Results. Ele­vat­ed total cho­les­te­rol, and tri­gly­ce­ride lev­els and nic­o­tine abuse were more fre­quent in ­patients young­er than 50 years. Dia­betes mel­lit­us and hyper­ten­sion were more fre­quent in ­patients older than 75 years. The dif­fer­ent fre­quen­cies for smok­ing, dia­betes mel­lit­us and hyper­ten­sion were age-relat­ed (p<0.05). Con­cern­ing labor­a­to­ry param­e­ters such as HDL- and LDL-cho­les­te­rol, fibrino­gen, lip­o­pro­tein(a) and homo­cys­teine there were no rel­e­vant age-relat­ed dif­fer­enc­es in fre­quen­cy nor in abso­lute val­ues with the excep­tion of the hem­a­toc­rit and uric acid. The coin­ci­dence with clin­i­cally man­i­fest myo­car­dial infarc­tion was 11.15% in the ­patients under 50 years com­pared to 20.6% in those aged 51-74 years and 16.4% in those over 75 years, for cere­bral ­stroke it was 5.6%, 17.5% and 14.5%, respec­tive­ly. ­Patients under 50 years with periph­er­al arte­ri­al occlu­sive dis­ease and a his­to­ry of myo­car­dial infarc­tion were char­ac­ter­ised by high lev­els of total cho­les­te­rol, tri­gly­ce­ride and lip­o­pro­tein(a). Exclud­ing ­patients with prior myo­car­dial infarc­tion ­patients did not show any dif­fer­ence in risk pro­file ­between the three age ­groups.
Con­clu­sions. In a pop­u­la­tion suf­fer­ing from man­i­fest periph­er­al arte­ri­al occlu­sive dis­ease the risk pro­file in ­patients under 50 years is not dif­fer­ent from that in older ­patients. In con­trast an addi­tion­al myo­car­dial infarc­tion in such a pop­u­la­tion is asso­ciat­ed with path­o­log­i­cal lipid pro­files.

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