CASE REPORT   

Gazzetta Medica Italiana - Archivio per le Scienze Mediche 2022 October;181(10):788-91

DOI: 10.23736/S0393-3660.21.04622-2

Copyright © 2021 EDIZIONI MINERVA MEDICA

language: English

Shulman Syndrome: a clinical case, two rare associations

Ana R. LOPES ✉, Lília C. BRANCO, Cátia PEREIRA, Margarida COELHO, Elisabete PINELO

Department Of Internal Medicine, Unidade Local de Saúde do Nordeste, Bragança, Portugal

Overlap syndromes are rare and characterized by the presence of two or more autoimmune disease in the same patient. The association between Shulman syndrome, mixed connective tissue disease and spondyloarthropathy has not yet been described. The authors present the case of a 38-year-old patient with a clinical picture, with four months of evolution, of low back pain and migratory polyarthralgias with severe functional limitation associated with constitutional symptoms and Raynaud’s phenomenon, which led to an exhaustive investigation and together with the physical examination findings led to the diagnosis of 3 distinct autoimmune diseases, which up to now have not been described in the literature as present in the same patient.

KEY WORDS: Spondyloarthropathies; Eosinophilic fasciitis; Mixed connective tissue disease