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Gazzetta Medica Italiana - Archivio per le Scienze Mediche 2022 July-August;181(7-8):564-71

DOI: 10.23736/S0393-3660.22.04790-8

Copyright © 2022 EDIZIONI MINERVA MEDICA

language: English

Explore the role of irisin in mitohormesis by PGC-1α

Xu HAIBO 1, Ahmad ALBATTAT 1 , Jeong C. PHUOC 1, Wang BAOGUI 2

1 Graduate School of Management, Post Graduate Centre, Management and Science University, Selangor, Malaysia; 2 College of Biological and Environmental Engineering, Binzhou University, Binzhou, China



As the energy supply station of eukaryotic cells, mitochondria also produce superoxide such as O2 to destroy mitochondrial homeostasis while providing ATP for cells. If the homeostasis continues to be unbalanced, it will eventually lead to the occurrence of some mitochondria-related degenerative diseases. PGC-1α plays an important role in maintaining mitochondrial homeostasis by cooperating with many muscle factors. The myokine Irisin is induced by PGC-1α and establishes a new direction for the study of metabolic diseases. This paper uses the methods of literature materials, from the production of muscle factor Irisin to its related regulation, conducts a general analysis and discussion, and puts forward a feasibility research discussion. The study found that skeletal muscle secretion of the myokine Irisin is regulated by PGC-1α based on the body’s movement. During exercise stress, PGC-1α has a role in regulating mitochondrial homeostasis. Irisin has the ability to regulate mitochondrial homeostasis through PGC-1α. Mitochondria can reduce the production of a variety of degenerative-related diseases while maintaining homeostasis. Skeletal muscle, as a secretory organ, regulates the body’s adaptive changes by secreting myokines during exercise. The imbalance of mitochondrial homeostasis can cause many degenerative diseases in the body. Therefore, how to effectively maintain mitochondrial homeostasis is the basis for ensuring the normal energy supply of the body. By studying the effects of Irisin and PGC-1α on the regulation of mitochondrial homeostasis, it may provide new research targets for mitochondria-related degenerative diseases such as aging, tumors, and myopathy.


KEY WORDS: Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Homeostasis; Hormones

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