ORIGINAL ARTICLE   

Gazzetta Medica Italiana - Archivio per le Scienze Mediche 2022 May;181(5):337-43

DOI: 10.23736/S0393-3660.20.04531-3

Copyright © 2020 EDIZIONI MINERVA MEDICA

language: English

Features of metabolic disorders in women with polycystic ovary syndrome combined with obesity

Elena V. BOLOTOVA ¹, Anna V. DUDNIKOVA ² ✉, Fedor E. FILIPPOV ³, Victoria A. KRUTOVA ⁴, Natalia S. PROSOLUPOVA ², Anzhelika А. SOROCHENKO ²

¹ Department of Therapy, Faculty of Advanced Training and Retraining of Specialists, Clinic SBEI HPE, Kuban State Medical University, Krasnodar, Russia; ² Department of Consultative Diagnostic, Kuban State Medical University, Ministry of Health of the Russian Federation, Krasnodar, Russia; ³ Kuban State Medical University, Ministry of Health of the Russian Federation, Krasnodar, Russia; ⁴ Department of Obstetrics, Gynecology and Perinatology, Clinic SBEI HPE, Kuban State Medical University, Ministry of Health of the Russian Federation, Krasnodar, Russia

BACKGROUND: Obesity is considered a global epidemic and is one of the most significant medical and social problems. Research in recent years shows that in 25-45% of cases of obesity, polycystic ovary syndrome (PCOS) is detected. For this reason, the purpose of our study was to study the frequency and structure of metabolic disorders in obese women in combination with PCOS.
METHODS: The study included 136 participants. Group 1 included obese women without PCOS (59 patients), and group 2 included obese women with PCOS (45 patients), in the control group - 38 were healthy women. The study included clinical anthropometry with measurement of body weight, height, waist circumference (OT) and hip circumference (OB), followed by calculation of Body Mass Index (BMI) and OT/OB ratio, and measurement of blood pressure (BP). A biochemical blood test was performed, the hormonal status was examined, and an ultrasound examination of the pelvic organs was performed.
RESULTS: Among group 2 patients, dyslipidemia, visceral obesity, arterial hypertension, insulin resistance, hyperinsulinemia, and hyperuricemia were significantly more common (P<0.05). Correlations between BMI and triglycerides, testosterone and total cholesterol were found (P<0.05). Obese and PCOS patients had significantly higher levels of C-reactive protein (CRP), fibrinogen, anti-Müllerian hormone (AMH), and hepatic transaminases (P<0.05). Vitamin D deficiency was detected in 13.2% of patients, and insufficiency in 22.7% of patients. There is a statistically significant correlation between the level of 25 (OH)D and indicators of BMI, follicle-stimulating hormone, luteinizing hormone (P<0.05), the level of AMH (P=0.008).
СONCLUSIONS: A high frequency of metabolic disorders in obese women in combination with PCOS has been identified, which necessitates early screening, diagnosis and treatment of these disorders to strengthen reproductive health and prevent chronic non-communicable diseases.

KEY WORDS: Metabolic diseases; Obesity; Polycystic ovary syndrome