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Gazzetta Medica Italiana - Archivio per le Scienze Mediche 2022 January-February;181(1-2):15-8

DOI: 10.23736/S0393-3660.19.04204-9

Copyright © 2019 EDIZIONI MINERVA MEDICA

language: English

A study of thyroid function in patients with abnormal uterine bleeding

Nina A. MAHALE 1, Prathima K. N. 1, Ajit MAHALE 2 , Sonali PRABHU 2, Sonali ULLAL 2, Merwyn FERNANDES 2

1 Department of Obstetrics and Gynecology, Kasturba Medical College, Karnataka, India; 2 Department of Radiodiagnosis, Kasturba Medical College, Karnataka, India



BACKGROUND: Thyroid disorders are ten times more common in women than in men. The possibility of thyroid dysfunction must always be considered while investigating abnormal uterine bleeding, abnormal sexual development, delayed puberty, hirsuitism, infertility, and recurrent pregnancy loss. While activity of the thyroid gland is closely linked with the process of ovarian maturation, the thyroid gland is itself dependent on direct and indirect stimuli from the ovary to discharge its own function.1.
METHODS: This prospective study took place at Lady Goschen Hospital, Mangalore and KMC Attavar Hospital, from November 2016 to November 2018. Overall, 100 patients with abnormal uterine bleeding were studied. Serum T3, T4, and TSH were estimated by electrochemiluminescence method (ECLIA). Normal range for T3 is 0.6-2.02 ng/mL, T4 is 5.13-14.06 ng/mL, and TSH is 0.2-4.2 ng/mL.
RESULTS: The total number of cases studied were 100 and detailed analysis of these 100 cases of abnormal uterine bleeding (AUB)was done. Among the 100 cases studied, the commonest age group was 31-40 years. The commonest menstrual abnormality in hypothyroidism was menorrhagia. Twenty-five percent of women with AUB had thyroid dysfunction. Twenty-two patients had oligomenorrhoea and out of them three were hyperthyroid. Seventy-five percent of the patients were euthyroid.
CONCLUSIONS: Our study concludes that thyroid dysfunction should be considered as an important etiological factor in menstrual abnormalities. Thus biochemical evaluation of T3, T4, TSH should be done in abnormal uterine bleeding to detect apparent and occult thyroid dysfunction.


KEY WORDS: Thyroid gland; Thyroid function tests; Uterine hemorrhage

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