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Gazzetta Medica Italiana - Archivio per le Scienze Mediche 2021 July-August;180(7-8):380-6

DOI: 10.23736/S0393-3660.21.04635-0

Copyright © 2021 EDIZIONI MINERVA MEDICA

language: English

Rare malignant ovarian tumors-classification, incidence rate, prognosis and treatment

Yavor KORNOVSKI 1, Yonka IVANOVA 1, Stoyan KOSTOV 1, Stanislav SLAVCHEV 1, Svetlana MATEVA 2, Angel YORDANOV 3

1 Obstetrics and Gynecology Clinic, St. Anna University Hospital, Medical University of Varna, Varna, Bulgaria; 2 Department of Clinical Pathology, Medical University of Pleven, Pleven, Bulgaria; 3 Department of Gynecologic Oncology, Medical University of Pleven, Pleven, Bulgaria



The ovary is the most complex organ in the human body from a histological point of view. This is based on the rich variety of ovarian tumor formations that occur in it. In the ovary, in addition to non-proliferating, proliferating tumors also occur, which in turn can be benign, borderline and malignant. The most common malignancy is high-grade serous carcinoma, which accounts for 80% of all malignancies. Other neoplasms classified as rare malignant ovarian tumors are a very heterogeneous group in terms of biology, malignant potential, prognosis, and sensitivity to chemotherapy. The wide variety of histological types, the low incidence rate and the different aggressiveness of these tumors make them a challenge for pathologists, oncogynecologists and chemotherapists. With this review, we attempted to synthesize the most up-to-date literature data on the incidence rate, prognosis, and treatment options, including organ-sparing surgical techniques, for these rare tumors.


KEY WORDS: Ovarian neoplasms; Classification; Incidence; Prognosis; Therapeutics

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