ORIGINAL ARTICLE   

Gazzetta Medica Italiana - Archivio per le Scienze Mediche 2021 January-February;180(1-2):43-7

DOI: 10.23736/S0393-3660.19.04193-7

Copyright © 2019 EDIZIONI MINERVA MEDICA

language: English

Relationship between age, parity and history of chronic cough as a risk factor for uterine prolapse based on expression of mRNA and soluble protein estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ)

Imam A. FARID ¹ ✉, Mochammad HATTA ², Syahrul RAUF ³, Nusratuddin ABDULLAH ³

¹ Division of Urogynecology Reconstruction, Department of Obstetrics and Gynecology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; ² Department of Biology Molecular and Immunology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; ³ Department of Obstetrics and Gynecology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia

BACKGROUND: The function of estrogen is mainly mediated through specific intracellular estrogen receptors (ER) where those are the members of the super family of transcription factors that are activated by ligands expressed in the target tissue. This study aimed to determine the role of estrogen alpha (ERα) and estrogen beta (ERβ) receptor mRNA and serum protein levels with the risk of pelvic organ prolapse.
METHODS: This type of research is quantitative research using the case control design which is an observational analytic study that examines the relationship between effects on certain factors. This research was carried out in several education hospitals in the Department of Obstetrics and Gynecology of the medical faculty of Hasanuddin University in Makassar, South Sulawesi province.
RESULTS: This research resulted that age as a risk factor showed a significant association with ER Alpha mRNA expression (P=0.01), ER Beta mRNA expression (P=0.016), serum ER alpha protein level (P=0.008) and no significant association with serum ER betha levels (P=0.055). The greater the amount of parity, the greater the risk of pelvic organ prolapse. Chronic cough is a risk factor that affects the incidence of pelvic organ prolapse.
CONCLUSIONS: Age, parity and weightlifting history as a risk factors have a significant association with ER alpha mRNA expression, ER beta mRNA expression, serum alpha protein and serum beta protein.

KEY WORDS: Age factors; Parity; Cough; Uterine prolapse