![]() |
JOURNAL TOOLS |
Publishing options |
eTOC |
To subscribe |
Submit an article |
Recommend to your librarian |
ARTICLE TOOLS |
Publication history |
Reprints |
Permissions |
Cite this article as |
Share |


YOUR ACCOUNT
YOUR ORDERS
SHOPPING BASKET
Items: 0
Total amount: € 0,00
HOW TO ORDER
YOUR SUBSCRIPTIONS
YOUR ARTICLES
YOUR EBOOKS
COUPON
ACCESSIBILITY
ORIGINAL ARTICLE
Gazzetta Medica Italiana - Archivio per le Scienze Mediche 2020 September;179(9):496-504
DOI: 10.23736/S0393-3660.19.04144-5
Copyright © 2019 EDIZIONI MINERVA MEDICA
language: English
The effects of combined exercise program on several clinical parameters according to a MspI RFLP in ApoAII gene in obese middle-aged women
Hoon KIM 1, Jae K. LEE 2, 3 ✉
1 Department of Golf Industry, Daegu University, Gyeongsangbuk-do, South Korea; 2 Department of Leisure and Sports, Sahmyook University, Seoul, South Korea; 3 Research Institute for Behavioral Fitness and Medicine, Sahmyook University, Seoul, South Korea
BACKGROUND: We studied the effects of combined exercise program for 16 weeks on various clinical parameters including body composition, hemodynamic parameters, physical fitness factors and blood biochemical parameters according to a MspI RFLP in apolipoprotein AII(ApoAII) gene.
METHODS. A total of 23 obese middle-aged women above 30% of body fat (mean age 53.3±7.4 year) were participated in our study program, and they all completed this combined exercise program including aerobic and resistance exercise program for 16 weeks. A MspI restriction fragment length polymorphism (RFLP) in ApoAII gene was genotyped by polymerase chain reaction (PCR) amplification, digestion by MspI restriction enzyme and further 2% agarose gel electrophoresis.
RESULTS: Although this genetic polymorphism was not significantly associated with the changes of these clinical parameters in this study program as well as any baseline clinical parameters, there was the significant association between this genetic polymorphism and the baseline serum AST activity (P<0.05).
CONCLUSIONS: Our study suggest that a MspI RFLP in ApoAII gene might be one of the useful genetic markers related to liver function. However, because sample size in this study was yet modest, further studies using larger sample size will be required to confirm the functional role of this genetic polymorphism.
KEY WORDS: Exercise; Obesity; Women