Home > Journals > Gazzetta Medica Italiana Archivio per le Scienze Mediche > Past Issues > Gazzetta Medica Italiana - Archivio per le Scienze Mediche 2019 May;178(5) > Gazzetta Medica Italiana - Archivio per le Scienze Mediche 2019 May;178(5):245-8

CURRENT ISSUE
 

JOURNAL TOOLS

eTOC
To subscribe
Submit an article
Recommend to your librarian
 

ARTICLE TOOLS

Publication history
Reprints
Permissions
Cite this article as

 

ORIGINAL ARTICLE   

Gazzetta Medica Italiana - Archivio per le Scienze Mediche 2019 May;178(5):245-8

DOI: 10.23736/S0393-3660.18.03840-8

Copyright © 2018 EDIZIONI MINERVA MEDICA

language: English

Selective muscle microRNAs as novel biomarkers of aerobic or anaerobic exercise capacity

Andrea GAZOVA 1 , Ján KYSELOVIČ 2, Simona VALÁŠKOVÁ 3, Andrea RAGANOVÁ 1, Erika ZEMKOVÁ 4, Jana LABUDOVÁ 4, Ľuboš RUPČÍK 4, Oľga KYSELOVIČOVÁ 4

1 Institute of Pharmacology and Clinical Pharmacology, Faculty of Medicine, Comenius University, Bratislava, Slovakia; 2 Department of Internal Medicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia; 3 Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University, Bratislava, Slovakia; 4 Faculty of Physical Education and Sports, Comenius University, Bratislava, Slovakia



BACKGROUND: MicroRNAs are small non-coding RNAs of 18-22 nucleotides, which post-transcriptionally regulate gene expression via mRNA degradation or translational inhibition. During muscle cell differentiation, the largest changes in expression occur in miR-1, miR-133a and miR-499. MiR-1, promotes myoblast differentiation while miR-133 enhances their proliferation. MiR-29b targets various collagens thereby contributing to fibrosis of soft tissues. We hypothesized that the exercise-induced changes in expression of selective skeletal/cardiac muscle microRNAs are related to aerobic or anaerobic exercise performance capacity and may thereby serve as fitness biomarkers.
METHODS: We analyzed three groups of sport active individuals who have been involved in three different gymnastic disciplines-rhythmic, aerobic and artistic gymnastics. A group of college students with no regular sport activity served as controls. RT qPCR was used for analysis.
RESULTS: We found significant increase in miR-1 in plasma of gymnast performing aerobics and a significant increase in miR-499 in plasma samples of the rhythmic gymnasts. No significant change in the level of miR-29b or miR-133a were evident in the plasma of the gymnasts.
CONCLUSIONS: In summary, our data demonstrate the exercise-dependent regulation in the plasma levels of specific myomiRs from cardiac and skeletal muscle. The potential suitability of selective miRs as novel biomarkers of aerobic or anaerobic exercise capacity is indicated.


KEY WORDS: MicroRNAs - Work capacity evaluation - Biomarkers - Gymnastics

top of page