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ORIGINAL ARTICLE   

Gazzetta Medica Italiana - Archivio per le Scienze Mediche 2019 January-February;178(1-2):66-71

DOI: 10.23736/S0393-3660.17.03689-0

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

Exercise-induced β-endorphin release in the anterior cingulate cortex in sedentary and exercise-trained rats

Aliye GÜNDOĞDU, Mehmet SEYRAN, Y. Gül ÖZKAYA

Faculty of Sports Sciences, Akdeniz University, Antalya, Turkey



BACKGROUND: The purpose of this study was to investigate the β-endorphin (BE) release in the anterior cingulate cortex (ACC) at rest, and following an exhaustive exercise in sedentary and exercise-trained rats.
METHODS: Male Wistar rats were randomly assigned to a training (T), or control group (C). T group was subjected to moderate running exercise for 8 weeks, and an exhaustive exercise test was administered in both groups. A microdialysis probe was inserted into ACC, extracellular fluid samples collected in awake, freely moving animals at rest, and following exercise, and BE levels were measured in samples.
RESULTS: Acute exercise resulted an increase in BE in both groups, however, significant increases were observed only in sedentary animals.
CONCLUSIONS: In conclusion, our results demonstrated that although moderate exercise training induces an increase in BE levels in the ACC, salient increase occurs in sedentary group.


KEY WORDS: Beta-Endorphin - Exercise - Gyrus cinguli - Microdialysis - Opioid peptides - Physical exertion

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