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Gazzetta Medica Italiana Archivio per le Scienze Mediche 2018 March;177(3 Suppl 1):71-7

DOI: 10.23736/S0393-3660.18.03782-8

Copyright © 2018 EDIZIONI MINERVA MEDICA

language: English

Influence of ceruloplasmin on free radical oxidation at chronic physical activity of submaximal level

Lyudmila V. KRIVOKHIZHINA 1, Elena N. ERMOLAEVA 1 , Salavat A. KANTYUKOV 1, Dmitry M. SMIRNOV 1, Elena F. SURINA-MARYSHEVA 2

1 Department of Pathophysiology, South Ural State Medical University, Chelyabinsk, Russia; 2 Research Center of Sports Science, South Ural State University, Chelyabinsk, Russia


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BACKGROUND: The aim of the study was to determine the efficacy of ceruloplasmin influence on the intensity of free radical oxidation in whole blood and serum under chronic physical load of submaximal power under experimental conditions.
METHODS: Chronic physical activity of submaximal level was modelled on rats daily swimming within 30 minutes. During the first seven days, experimental rats daily floated without freight, while over the following two weeks, they floated with the freight of 2% of body weight. At days 9, 15, and 21, animals were exposed to additional physical activity and floated within 4 minutes with freight weighing 20% of body weight. Ceruloplasmin was entered for 1, 4 and 7 days of physical activity, in a total dose of 60 mg/kg of body weight. Blood sampling was made on days 9, 15, and 21, 15 to 20 minutes after loading.
RESULTS: In case of loading the blood serum chemiluminescence was increased, content of products of lipids peroxidation was increased, production of free radicals in neutrophils was decreased, general anti-oxidizing activity was increased. Entering of ceruloplasmin did not lead to recovery of reduced products of free radical neutrophils in case of loading.
CONCLUSIONS: Ceruloplasmin increased duration of the latent period, reflecting the total capacity of anti-oxidizing system, contributed to time limited normalization of an Iron-induced serum chemiluminescence and content of products of lipids peroxidation.


KEY WORDS: Physical activity - Ceruloplasmin - Free radical - Oxidative stress - Luminescence

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