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Gazzetta Medica Italiana Archivio per le Scienze Mediche 2018 November;177(11):624-9

DOI: 10.23736/S0393-3660.17.03615-4

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

Seroprevalence of Toxoplasma gondii, HBV and HCV infections

Mohammad ROSTAMI-NEJAD 1, Seyed-Reza MOHEBBI 2, Somayeh JAHANI-SHERAFAT 3, Farnoush BARZEGAR 4 , Hamid ASADZADE-AGHDAEI 2, Amir SADEGHI 1, Mohammad-Reza ZALI 1

1 Gastroenterology and Liver Diseases Research Center, Research Institute of Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2 Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 3 Foodborne and Waterborne Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 4 Student Research Committee, Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran


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BACKGROUND: Toxoplasma gondii (T. gondii) infections can cause serious complications in pregnant women, leading to miscarriage, stillbirth, birth defect and could possibly enhance the mother-to-child transmission of HCV and HBV vertical transmission. The aim of this study was to investigate the prevalence of T. gondii, HCV and HBV in a Iranian population of pregnant women.
METHODS: A retrospective cross sectional study was performed on 496 pregnant women in Lorestan province between August 2011 and October 2013. The study population was screened for anti-T. gondii (IgG & IgM), anti-HCV and anti-HBc using ELISA. Previous exposure to HBV infection was investigated by checking the Anti-HBc antibody positivity and HBV chronic infection was diagnosed through determining the presence of HBs Ag.
RESULTS: In this study 496 pregnant women with mean age 25.9 and mean pregnancy 5.25 were investigated. The prevalence of anti-T. gondii, anti-HCV, and anti-HBc in pregnant women was 31%, 5%, and 0.4%, respectively. Of the 25 positive samples, 5 (1%) were positive for HBsAg. None of the infected subjects with T. gondii were infected by HBV and HCV.
CONCLUSIONS: The results of this study show that the high level of education and preferment of general health awareness might be reduce the risk of these infections. Nevertheless, 70% of pregnant women in this study did not have previous history of toxoplasma infection and they may have been exposed to primary infectin and thereby acute disease. On the other hand these results emphasize the need for prenatal screening for HBV infection in pregnant women and treatment of newborns from HBsAg-positive mothers. Therefore, for all investigated parameters in this study, prevention, control and educational programs are necessary.


KEY WORDS: Seroepidemiologic studies - Toxoplasmosis - Pregnant women - Hepacivirus - Hepatitis B virus

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