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SPECIAL ARTICLE  INFECTIOUS DISEASES AND CHEMOTHERAPY CONSEQUENCES: AN INVESTIGATION TO IMPROVE THE QUALITY OF LIFE IN PATIENTS 

Gazzetta Medica Italiana Archivio per le Scienze Mediche 2018 October;177(10):537-42

DOI: 10.23736/S0393-3660.18.03818-4

Copyright © 2018 EDIZIONI MINERVA MEDICA

language: English

Conventional T cells and non-conventional T cells during Mycobacterium tuberculosis infection. An emerging issue in adult and children population

Marco P. LA MANNA 1 , Giuliana GUADAGNINO 2, Anna M. DE LUCA 2, Chiara IARIA 3, Francesco SCARLATA 2, Nicola SERRA 4, Teresa REA 4, Salvatrice MANCUSO 5, Davide MILILLI 2, Claudia GIOÈ 2, Benedetta ROMANIN 2, Claudia COLOMBA 2

1 Biopathology and Medical Biotechnologies, University of Palermo, Palermo, Italy; 2 Department of Health Promotion Sciences and Mother and Child Care “G. D’Alessandro”, University of Palermo, Palermo, Italy; 3 Unit of Infectious Diseases - ARNAS Civico, Di Cristina, Benfratelli, Palermo, Italy; 4 School of Medicine and Surgery, University Federico II of Naples, Naples, Italy; 5 Biomedical Department of Internal and Specialized Medicine (Di.Bi.Mi.S), "Paolo Giaccone" Policlinic, University of Palermo, Palermo, Italy


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This paper focuses on cellular immune response to Mycobacterium tuberculosis according to our studies conducted at our laboratory in the last 20 years. T cells are critical components of the immune response to Mycobacterium tuberculosis. IFN-γ is a key effector function of T cells during infection, but alone is not sufficient to control M. tuberculosis. The role of other T cells likely natural killer T cells and γδ T cells and/or different subset of monocytes-macrophages remark the role of no conventional T cells into control of Mycobacterium tuberculosis infection in different phase of the disease.


KEY WORDS: Mycobacterium tuberculosis - T-lymphocytes - Natural killer T-cells

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