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Gazzetta Medica Italiana Archivio per le Scienze Mediche 2018 April;177(4):158-64

DOI: 10.23736/S0393-3660.17.03508-2

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

Genetic polymorphism of CYP2D6*41 in different ethnicities of Iranian population

Zohre POURKARAMI 1, 2, M. Hosein SANGTARASH 2, Narges JAFARZADEH 1, Zohre POURSINA 3, Azra IZANLOO 1, Masoud HOUSHMAND 4

1 Razavi Cancer Research Center, Razavi Hospital, Imam Reza International University, Mashhad, Iran; 2 Department of Biology, Faculty of Basic Sciences, University of Sistan and Balouchestan, Zahedan, Iran; 3 Department of Biology, Faculty of Basic Sciences, Islamic Azad university East Tehran Branch, Tehran, Iran; 4 Department of Medical Genetics, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran


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BACKGROUND: We investigated the frequency, prevalence and distribution of CYP2D6*41 polymorphism among different ethnicities of Iranian population.
METHODS: Genotyping was performed using PCR-RFLP method on genomic DNA of blood samples from 300 healthy individuals. Then, DNA sequencing technique was applied on some random samples to confirm the results.
RESULTS: Allele frequencies were 64% and 36% for CYP2D6*41[2988G] and CYP2D6*41[2988A]. The most frequency of CYP2D6*41[2988A] allele in ethnicities was owned by Lur ethnicity (42%) and in terms of geographical distribution, the highest prevalence was seen in the southern areas of the country.
CONCLUSIONS: According to this data, lower drug dose should be considered for people who show this polymorphism rather than normal individuals.


KEY WORDS: Pharmacokinetics - Polymorphism, genetic - Cytochrome P-450 enzyme system

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