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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE

A Journal on Internal Medicine and Pharmacology


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Gazzetta Medica Italiana Archivio per le Scienze Mediche 2018 March;177(3):65-71

DOI: 10.23736/S0393-3660.17.03497-0

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

Effect of L-arginine alpha ketoglutarate supplementation on hormonal response during recovery in male endurance swimmers

Alireza MOOSAKHANI , Siroos CHOOBINEH, Rahman SOORI

Faculty of Physical Education and Sports Sciences, University of Tehran, Tehran, Iran


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BACKGROUND: Nowadays, due to the epidemic of sports supplements, the effects of these supplements on athletic performance require analysis and evaluation. As a result, the aim of the study was to determine the effect of L-arginine alpha ketoglutarate supplementation on the responses of some hormonal factors during recovery period in male endurance swimmers.
METHODS: In a randomized double-blind clinical trial, 24 endurance male swimmers (age: 30±5 years, weight: 78±7.5 kg, BMI: 24±35 kg/m2) were randomly divided into two groups, ARG (N.=12) and placebo (N.=12), and they underwent 7 days of L-arginine alpha ketoglutarate supplementation with 7 g/day L-arginine or placebo. Before and after supplementation a 1500m swimming test (freestyle) involved with maximum effort. Data were collected before, immediately after (0 min) and at 5 min, 30 min and 60 min after swimming test for measurement of serum insulin, growth hormone, testosterone, cortisol, prolactin, lactate and glucose concentrations. Data were analyzed by two-way ANOVA repeated measure (P<0.05).
RESULTS: In ARG group, Insulin hormone levels decreased significantly before exercise test (P=0.04) and increased immediately after exercise test (P=0.002). GH increased at 60 min (P=0.46). Cortisol decreased at 30 min (P=0.001) and 60 min (P=0.036). Moreover, in the aggregate testosterone increased and insulin decreased (P<0.05) as treatment effect by ANOVA repeated measure factors. There were no significant changes in serum lactate, glucose or prolactin after supplementation between L-arginine and placebo.
CONCLUSIONS: In one word, perhaps L-arginine alpha ketoglutarate can have some positive effects on recovery period in endurance swimmers by affected anabolic hormones.


KEY WORDS: Insulin - Testosterone - Hydrocortisone - Growth hormone - Glucose - Lactates

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Publication History

Issue published online: February 22, 2018
Manuscript accepted: March 10, 2017
Manuscript received: February 10, 2017

Cite this article as

Moosakhani A, Choobineh S, Soori R. Effect of L-arginine alpha ketoglutarate supplementation on hormonal response during recovery in male endurance swimmers. Gazz Med Ital - Arch Sci Med 2018;177:65-71. DOI: 10.23736/S0393-3660.17.03497-0

Corresponding author e-mail

ar.moosakhani@alumni.ut.ac.ir