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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE

A Journal on Internal Medicine and Pharmacology


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Gazzetta Medica Italiana Archivio per le Scienze Mediche 2018 January-February;177(1-2):1-7

DOI: 10.23736/S0393-3660.17.03493-3

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

The effects of anemia on oxidative stress and apoptosis in the placenta

Raziye DESDICIOGLU 1 , Fevziye B. SIRIN 2, Fatma SIMSEK 3, Gonca G. GULBAS TANRISEVER 4, Recep SUTCU 5, Sefa KELEKCI 6

1 Department of Obstetrics and Gynecolgy, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey; 2 Ataturk Training and Research Hospital Biochemistry Department, Katip Celebi University, Izmir, Turkey; 3 Department of Histology and Embriology, Faculty of Medicine, Katip Celebi University, Izmir, Turkey; 4 Department of Obstetrics and Gynecology, Van Training and Research Hospital, Van, Turkey; 5 Department of Biochemistry, Faculty of Medicine, Katip Celebi University, Izmir, Turkey; 6 Department of Obstetrics and Gynecology, Faculty of Medicine, Katip Celebi University, Izmir, Turkey


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BACKGROUND: Maternal anemia is a common public health problem. Anemia has some effects on placental apoptosis and oxidative stress. In this study, we aimed to investigate the oxidative stress, antioxidant state and apoptotic findings in the placental tissues of pregnant women with iron deficiency anemia.
METHODS: A total of 35 placentas were evaluated (13 anemic and 22 non-anemic). Placental malondialdehyde (MDA) level, catalase (CAT), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) enzyme activities and apoptotic cell ratio were measured.
RESULTS: There was no difference in the results for maternal age, neonatal measurements and delivery weeks between the two groups. MDA and CAT measurement results were not different between the two groups, while GSH-PX and SOD levels were increased in placentas of the anemic group. The percentage of apoptosis in placentas of the anemic group was significantly higher than in the non-anemic group.
CONCLUSIONS: The evidence from antioxidant enzyme levels, as well as the increase in apoptosis, in the placenta of anemic pregnant women is important due to the close relationship between these two mechanisms. In order to avoid negative clinical findings that are secondary to placental apoptosis in anemic patients, necessary treatments must be provided to allow hemoglobin levels to reach normal limits.


KEY WORDS: Anemia - Antioxidants - Apoptosis - Oxidative stress - Placenta

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Publication History

Issue published online: December 6, 2017
Manuscript accepted: March 10, 2017
Manuscript received: February 2, 2017

Cite this article as

Desdicioglu R, Sirin FB, Simsek F, Gulbas Tanrısever GG, Sutcu R, Kelekci S. The effects of anemia on oxidative stress and apoptosis in the placenta. Gazz Med Ital - Arch Sci Med 2018;177:1-7. DOI: 10.23736/S0393-3660.17.03493-3

Corresponding author e-mail

raziyedesdicioglu@gmail.com