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Gazzetta Medica Italiana Archivio per le Scienze Mediche 2017 October;176(10):550-6

DOI: 10.23736/S0393-3660.16.03408-2

Copyright © 2016 EDIZIONI MINERVA MEDICA

language: English

Serological markers (immunoglobulin G, immunoglobulin M) and ocular toxoplasma: a meta-analysis study

Mohammad EBADI, Saeid EBADI

Department of Ophthalmology, Semmelweis University Budapest, Budapest, Hungary


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BACKGROUND: Ocular toxoplasmosis results from retinal infection with the protozoan, Toxoplasma gondii. The main objective of this study was to evaluate the IgG , IgM antibodies and development of Ocular toxoplasma.
EVIDENCE ACQUISITION: A published literature search was performed through Pubmed, Cochrane Library, Medline, and Science Citation Index Expanded databases for articles published in English. Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using random or fixed effects models. Heterogeneity was assessed using Chi-square and I2 statistics.
EVIDENCE SYNTHESIS: In total, 4 published studies were included in the final analysis. Using the Random-effect model, meta-analysis showed that the seroprevalence for IgG was 43.1 (95% CI: 39.76 to 46.87, P =0.00) and that for IgM was 1.21 (95% CI: 0.98 to 1.50, P =0.07).
CONCLUSIONS: In this meta-analysis, there was evidence indicated that positive serum anti-toxoplasma IgG, IgM antibodies and Ocular toxoplasma.


KEY WORDS: Serologic tests - Immunoglobulin G - Immunoglobulin M - Toxoplasma

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