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Gazzetta Medica Italiana Archivio per le Scienze Mediche 2017 July-August;176(7-8):415-8

DOI: 10.23736/S0393-3660.16.03397-0

Copyright © 2016 EDIZIONI MINERVA MEDICA

language: English

Evaluating the efficacy of fractional Nd-YAG laser plus hydroquinone in the treatment of facial melasma

Setareh TEHRANI 1, Seyedeh G. ZIAIE 1, Paniz NEJATI 1, Sepideh TEHRANI 1, Seyed M. SHUSHTARIAN 1, Sedigheh JOUGHEHDOUST 2

1 Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran; 2 Department of Engineering, Shahrood Branch, Islamic Azad University, Shahrood, Iran


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BACKGROUNDː Melasma is an acquired symmetric hypermelanosis characterized by brown pigmentation that usually occurs in sun-exposed skin. Since recurrent melasma was reported with the mono therapy, using fractional Nd-YAG laser plus topical Hydroquinone may be last longer.
METHODSː To determine the effectiveness of using combinational therapy (fractional Nd-YAG laser and 4% Hydroquinone) in treatment of melasma, these patients were randomly divided in two groups (Group A=16 patients of melasma treated with fractional Nd-YAG laser at 2 weeks interval plus 4% Hydroquinone daily, Group B=6 patients of melasma treated with 4% Hydroquinone alone). To evaluating the responsiveness of the treatment, before treatment photos were compared with after treatment photos.
RESULTSː After 8 sessions laser therapy, the positive response was 93.8% and 81.3% in group A and B, respectively (P>0.05). After 4 months, complete remission was seen in 2 patients (12.5%) in group A and 1 patient (6.3%) in group B.
CONCLUSIONSː The results of this study demonstrated that the combination of fractional Nd-YAG laser and 4% Hydroquinone may be a good therapeutic option in the treatment of melasma.


KEY WORDS: Lasers, solid-state - Hydroquinone - Melanosis - Therapeutics

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