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Gazzetta Medica Italiana Archivio per le Scienze Mediche 2017 July-August;176(7-8):412-4

DOI: 10.23736/S0393-3660.17.03351-4

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

Hypothyroidism in children with type 1 diabetes mellitus: an observational study

Reetha GOPINATH , Ravikumar PAYORA, Mohammed M. PEEDIKAYIL

Department of Pediatrics, Pariyaram Medical College, Academy of Medical Sciences, Pariyaram, India


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BACKGROUND: Type 1 diabetes mellitus is an autoimmune disorder which is associated with other autoimmune disorders of which autoimmune thyroid disorders are the commonest. The aim of the study was to find out the prevalence of hypothyroidism at diagnosis in children with type 1 diabetes mellitus.
METHODS: Retrospective observational hospital-based case study conducted at a tertiary care teaching hospital. 58 patients from a hospital based sample with type 1 diabetes were included in the study. Children attending the Pediatric Diabetic Clinic, who were diagnosed outside were also included if they had the investigations done at the time of diagnosis. Hypothyroidism was diagnosed based on the thyroid function tests (TFT). Those children who were found to have abnormal TFT were further investigated for presence of anti-thyroid antibodies, anti-thyroglobulin (anti-TG), and anti-thyroid peroxidase (anti-TPO).
RESULTS: There were a total of 58 children in the study group. Out of which five children were found to be hypothyroid giving a prevalence 8.6%. Prevalence of positivity for anti-TPO antibody and anti-TG antibody was 6.89% and 3.44%, respectively, and the prevalence of positivity for both antibodies was 3.44%.
CONCLUSIONS: Significant numbers of children with type 1 diabetes mellitus have associated thyroid function abnormalities. Therefore, these children need to be tested for thyroid hormones and antibodies.


KEY WORDS: Type 1 diabetes mellitus - Hypothyroidism - Anti-thyroglobulin

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