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Gazzetta Medica Italiana Archivio per le Scienze Mediche 2017 July-August;176(7-8):408-11

DOI: 10.23736/S0393-3660.16.03391-X

Copyright © 2016 EDIZIONI MINERVA MEDICA

language: English

Directly measured low density lipoprotein cholesterol versus calculated LDL cholesterol by Friedewald formula in a Latin-American population

Carlos E. BUILES-MONTAÑO 1 , Natalia ARISTIZABAL 2, Maria del Pilar LONDOÑO 2, Alejandro ROMÁN-GONZÁLEZ 2, Esteban ECHAVARRÍA 3, Juan M. TORO 1

1 Unit of Endocrinology, Department of Internal Medicine, Pablo Tobón Uribe Hospital, University of Antioquia, Medellín, Colombia; 2 Unit of Endocrinology, Pontificia Bolivariana University, Medellín, Colombia; 3 Clinic Laboratory Las Américas, Medellín, Colombia


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BACKGROUND: Atherosclerotic disease and its complications are the leading causes of death in people over 45 years in Colombia and LDL cholesterol levels have an exponentially relation with the risk of acute myocardial infarction. It is generally recommended to calculate the value of LDL cholesterol using the Friedewald formula. The aim of this study was to estimate in a population of the city of Medellin the correlation between the value of LDL cholesterol by direct measurement with the LDL cholesterol calculated by the Friedewald formula. In an exploratory manner estimate the correlation with the formula proposed by Cordova and Cordova.
METHODS: This is a descriptive study of the correlation between LDL cholesterol value measured and calculated by the Friedewald formula in persons between 18 and 75 years with triglyceride levels below 400 mg.
RESULTS: Data from 454 persons were obtain, 61% were women, mean age was 50.7 years (SD±16.2), the mean measured LDL cholesterol was 123mg/dL (SD±36) and the calculated by the Friedewald formula was 119 mg/dL (SD±36), the correlation maintain between the different groups.
CONCLUSIONS: In a population of Medellín both formulas show a very good correlation with the measured cholesterol and this is maintained regardless of the value of triglycerides, age and sex.


KEY WORDS: Cholesterol - Cholesterol, LDL - Latin America

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