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GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE

A Journal on Internal Medicine and Pharmacology


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Gazzetta Medica Italiana Archivio per le Scienze Mediche 2017 May;176(5):308-13

DOI: 10.23736/S0393-3660.16.03350-7

Copyright © 2016 EDIZIONI MINERVA MEDICA

language: English

Clinical presentations of children and adolescents with celiac disease in an Iranian population

Maryam TAGHDIR 1, 2, Naser HONAR 3, Seyed M. MAZLOOMI 4, Mojtaba SEPANDI 5, Mahkameh ASHOURPOUR 2, Mahmoud HAGHIGHAT 3, Musa SALEHI 2

1 Department of Nutrition and Food Hygiene, Faculty of Health, Baqiyatallah University of Medical Sciences, Tehran, Iran; 2 Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran; 3 Department of Pediatric Gastroenterology and Hepatology, Shiraz University of Medical Sciences, Shiraz, Iran; 4 Department of Food Hygiene and Quality Control, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran; 5 Gastrointestinal and Liver Diseases Research Center, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran


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BACKGROUND: The aim of this study was to describe clinical features of children and adolescents with celiac disease (CD) and to assess if the presenting symptoms vary with age and sex.
METHODS: In this cross-sectional study, a total of 65 known cases of patients with CD, both males and females whom diagnosed in Namazi Hospital, a large referral center in south of Iran, by census were studied in 2014. A detailed data about clinical features and associated disorders, for all patients were assessed based on their medical records and also clinical examination. Two groups were made as per the age of the patients at the time of diagnosis, groups I (less than or equal to 10 years old) and II (11-18 years old).
RESULTS: The mean age at diagnosis was 8.11 years. Growth failure and abdominal pain were the most frequent presenting features. Diarrhea was more common in females (36.8% vs. 18.5%, P=0.1). The most common presenting features in group I were growth failure, abdominal pain and anorexia and in group II were growth failure, short stature and abdominal pain. All cases of convulsion were male (P=0.03). Both abdominal distention (46% vs. 18.5%, P=0.02) and anxiety (34.2% vs. 11.1%, P=0.03) were more common among female participants. The most frequently associated disorder was diabetes mellitus type 1 (5 patients).
CONCLUSIONS: CD should be considered in children and adolescents with growth failure or short stature, even in the absence of gastrointestinal symptoms, especially diarrhea.


KEY WORDS: Celiac disease - Adolescent - Child

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Publication History

Issue published online: March 9, 2017
Manuscript accepted: May 12, 2016
Manuscript received: March 16, 2016

Cite this article as

Taghdir M, Honar N, Mazloomi SM, Sepandi M, Ashourpour M, Haghighat M, et al. Clinical presentations of children and adolescents with celiac disease in an Iranian population. Gazz Med Ital - Arch Sci Med 2017;176:308-13. DOI: 10.23736/S0393-3660.16.03350-7

Corresponding author e-mail

Salehi@sums.ac.ir