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Gazzetta Medica Italiana Archivio per le Scienze Mediche 2017 May;176(5):257-64

DOI: 10.23736/S0393-3660.16.03353-2


language: English

Acute effects of zaleplon on daytime functions on the following day: psychomotor and physical performances, arousal levels and mood

Wakako ITO 1, Takashi KANBAYASHI 1, Kazumi SHIMIZU 1, Sachiko U. ITO 2, Masahiko WAKASA 2, Yuichi INOUE 3, Tetsuo SHIMIZU 1, Seiji NISHINO 4

1 Department of Psychiatry, Akita University Graduate School of Medicine, Akita, Japan; 2 Department of Physical Therapy, Akita University Graduate School of Health Sciences, Akita, Japan; 3 Department of Somnology, Tokyo Medical University, Tokyo, Japan; 4 Sleep and Circadian Neurobiology Laboratory, Stanford University Sleep Research Center, Palo Alto, CA, USA


BACKGROUND: Sleep problems are commonly experienced by athletes. Although taking hypnotics is one of the treatments for insomnia, a major problem with use of these drugs is the residual effects. The aim of this study was to assess residual effects of zaleplon on psychomotor functions, physical performances, mood and subjective sleep evaluations.
METHODS: Single oral doses of zaleplon (10 mg) or placebo was administered before going to bed in a randomized double-blind, cross-over design to eleven athletes. These assessments were conducted at 9:00 h, 13:00 h and 17:00 h on the following day.
RESULTS: Zaleplon did affect neither subjective sleep evaluations, psychomotor nor physical performances (simple discrimination reaction, digit symbol substitution, finger tapping, forward bending, right grip strength, right quadriceps femoris muscle strength, and repeated side jumps), nor mood (Profile of Mood State). The score of alertness with visual analog scale in placebo condition was significantly worse at 13:00 h compared to 9:00 h and 17:00 h, while no changes were seen in the zaleplon condition. Critical flicker fusion test (CFF) showed significantly better results in the zaleplon condition than in the placebo condition across the day.
CONCLUSIONS: These results indicated zaleplon may have enhanced the level of vigilance on the following day, which may be the withdrawal from the hypnotic. However, zaleplon did not impair any evaluations compared to the placebo session. We concluded that a use of zaleplon may not be contradicted in athletes for avoiding sleep disturbances the night before sports events.

KEY WORDS: Zaleplon - Motor activity - Sports

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