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Gazzetta Medica Italiana Archivio per le Scienze Mediche 2012 April;171(2):237-9

Copyright © 2012 EDIZIONI MINERVA MEDICA

language: English

A rare complication due to propylthiouracil use: lupus-like syndrome

Gul O. O., Unal O. K., Cander S., Tuncel E., Imamoglu S.

Department of Endocrinology and Metabolism, Uludag University Medical School, Bursa, Turkey


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Propylthiouracil and methimazole are frequently used in the management of hyperthyroidism. A 36 year old female patient with toxic multinodular goiter, developed polyarthralgia, neutropenia, hypergammaglobulinemia, and microscopic hematuria after treatment with propylthiouracil (PTU). Antinuclear antibody (ANA) was positive whereas anti-double stranded DNA, antihistone antibody were negative. PTU was discontinued and all symptoms subsided gradually. All these findings suggest that she developed a PTU-induced lupus-like syndrome.

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