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Gazzetta Medica Italiana Archivio per le Scienze Mediche 2008 October;167(5):237-46

Copyright © 2008 EDIZIONI MINERVA MEDICA

language: English, Italian

Primary or secondary multiple myeloma of the oral cavity? Case report and literature review

Angiero F. 1, Tete S. 2, Magistro S. 3, Periti G. 3, Farronato D. 3, Stefani M. 1

1 Sezione di Istopatologia Orale Istituto di Anatomia Patologica Università degli Studi di Milano, Milano, Italy 2 Università degli Studi di Chieti, Chieti, Italy 3 Istituto di Clinica Odontoiatrica e Stomatologica Università degli Studi di Milano, Milano, Italy


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Multiple myeloma is a malignant tumor characterized by the proliferation of plasma cells derived from a single clone. Although the tumor chiefly involves the skeletal hemopoietic bone marrow, the mandible or maxilla are secondary sites in 70% to 95% of cases and the primary site in about 12% of all malignant plasma cell tumors. A 66-year-old woman presented with a mass of the mandible (gingiva/alveolus),reddened gums and hypermobility of the adjacent teeth. Orthopantomographic examination showed a lytic radiotranslucent area of the right mandible; histology revealed a plasma cells neoplasia characterized by positive gamma plasma cells. Blood chemistry tests detected elevated serum monoclonal protein (M component) and urine tests showed Bence Jones protein. The article reports a case of primary-site multiple myeloma in the mandible and describes the clinical course, the approach to treatment and the implications of this tumor in the oral cavity.

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