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Gazzetta Medica Italiana Archivio per le Scienze Mediche 2008 June;167(3):123-7

Copyright © 2008 EDIZIONI MINERVA MEDICA

language: Italian

D-dimer measurement as an exclusionary test in patients with clinically suspected pulmonary embolism: the clinical utility of different laboratory methods

Sicilia S. 1, Formaro C. 1, Urso D. L. 2, Vincenzo D. 2, Pignataro F. 2, Sero A. 3, Cosentino N. 4

1 U.O. di Patologia Clinica, P.O.”V. Cosentino” di Cariati, Cosenza 2 U.O. di Pronto Soccorso P.O.”V. Cosentino” di Cariati, Cosenza 3 SUEM 118 Cosenza 4 U.O. di Cardiologia P.O. ”V. Cosentino” di Cariati, Cosenza


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Pulmonary embolism (PE) is relatively frequent acute disease. The diagnosis of PE is difficult because the clinical diagnosis is nonspecific and all of the objective tests have limitations. Pulmonary angiography, the gold standard for diagnosing PE, is invasive, costly and not universally available. Moreover, PE is confirmed in only approximately 30% of patients in whom it is suspected, rendering noninvasive screening tests necessary. The limitations of the current diagnostic is showed the clinical validity of the combination of a pretest clinical probability score and a D-dimer test in the initial evaluation of patients suspected of PE. Levels of D-dimer, a fibrin-specific product, are increased in patients with acute thrombosis; this may simplify the diagnosis as an exclusionary test of PE. The aim this study is to determine the clinical utility of different methods of D-dimer measurement.

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