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Gazzetta Medica Italiana Archivio per le Scienze Mediche 2006 December;165(6):265-7


language: English

Giant breast myofibroblastoma. A case report

De Andrade F. F. 1, De M. Andrade F. H. F. 2, Martins De Aquino L. C. 3, Freire De Carvalho M. G. 4, Gonçalves A. K. S. 4, Da Conceição Cornetta M. 4, De Araujo A. C. T. B. 4

1 Cel Pedro Germano Hospital, Natal, Brazil; 2 Health Science University of Alagoas, Maceio, Brazil; 3 Medicine School of Juazeiro do Norte, Juazeiro do Norte, Brazil; 4 Federal University of Rio Grande do Norte, Natal, Brazil


Myofibroblastoma of the breast is a rare benign neoplasm, reported more frequently in males associated with gynecomastia. Its pathogenesis remains unknown. Histologically these tumors show a varied cellularity, often confused with sarcomas, without, however presenting pleomorphism, atypical tumoral necrosis and mitoses. These tumors must be differentiated from inflammatory processes and other benign neoplasm, such as: fasciitis, fibromatosis, lipomas, neurofibromas and leiomiomas. Case report: This report describes a case of giant myofibroblastoma of the female breast. The tumor presented a fast growth, which motivated incisional biopsy. The diagnosis was myofibroblastoma. Faced with this result, a complete removal of the lesion was indicated and at the moment of surgery it measured 12,0×8,0 ×6,0 cm in diameter and weighed 400 grams. The histopathology showed myofibroblastoma of the breast with hyper cellular areas and three mitosis in 10HPF. These findings indicate the possibility of recurrences. The inmunohistochemical test was positive for calponin and negative to the other tumor markers (actin, CD34, desmin, S-100 protein, 40, 48, 50 and 50.6 kDa citoqueratin) and estrogen/progesterone receptor. The patient has been free of illness for the past 26 months of treatment. We emphasize that this diagnosis is difficult to establish, owing to the rarity of this variant and clinical presentation. Local excision is curative and to date, there are no reported cases of recurrence or distant metastasis. The importance of diagnosing this lesion accurately is emphasized here to avoid extensive and radical surgery.

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