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Gazzetta Medica Italiana Archivio per le Scienze Mediche 2005 April;164(2):101-7


language: English

N-oleoyl-phosphatidylethanolamine reduces food intake and body weight of dietary obese rats ameliorating their antioxidant status

Broccali G., Berti M., Pistolesi E., Cestaro B.

B.T. Biotecnica, Unit Research in Food and Nutrition, Saronno, Varese, Italy


Aim. We were interested in studying the possible in vivo anorexic effect of this NOPE-EGCG complex supplied per os as a natural source of the NOE in a rat model of obesity - producing diet, rich in saturated lipid and cholesterol. An additional objective of the present investigation was also to verify the possible NOPE-EGCG complex-induced amelioration of both plasma and liver antioxidant levels and functions.
Methods. The experimental protocol was the following: 36 Sprague-Dawley rats (6 weeks old), weighing 100-110 g were used. One group of 12 rats (group 1) was fed with the standard diet. The other 24 rats were divided into 2 groups: group 2 was fed with the obesity-producing diet and group 3 with the same diet plus the N-oleoyl-phosphatidylethanolamine and the green tea catechins.
Results. Treatment for 8 weeks with a diet rich in satured fats and cholesterol compared to a standard diet, induced a dramatic increase in the body weight and fat content of rats, with a decrease in protein mass and in the hydratation state of the tissues. There was also a significant increase in blood levels of triglycerides, total cholesterol and glucose. The levels of malonyldialdehyde (an index of lipoperoxides content) in the plasma and liver had also increased. There was also a decrease of reduced glutathione, ATP, and membrane “fluidity” in the liver.
Conclusion. All these potential atherogenic risks can be counteracted when the N-oleoyl-phosphatidylethanolamine (a phospholipid present in food such as soja, egg, chocolate, etc. …) is added to the diet. The phospholipid is able to reduce the food intake in the rats probably through a mechanism that augments the endogenous level in the gut of its N-oleoyletha-nolamine derivative, a lipid mediator involved in the peripheral regulation of feeding.

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